Primanti Brothers   

When you're looking for a sandwich that's a meal in itself, head to Primanti Bros. This location on the Strip is the original -- it's been here since 1933 -- but legend has it you could buy Primanti Bros. sandwiches from a horse and buggy in the '20s. Open 24/7 and boasting a publike interior (thanks in no small part to a full-service bar), this joint looms large over run-of-the-mill diners. Guide your group to a table, or sit at the counter and supervise the construction of your sandwich. Just make sure you're ready to knock elbows during lunch and just after the neighborhood bars close. The sandwiches come with tomatoes and coleslaw, stuffed between two thick slabs of Italian bread with loads of meat and cheese. The cheesesteak is a favorite, as are the juicy burgers. Early riser? Try the deluxe double egg-and-cheese sandwich, Pittsburgh's breakfast of champions.